June 18, 2021

IBAL Components Hydrogen Sulfate Ions

Hydrogen Sulfate


This bisulfate ion, a form of sulfuric acid that behaves as a Brønsted–Lowry acid and is deprotonated. In dilute solutions the hydrogen sulfate ions also dissociate, forming more hydronium ions and sulfate ions.


Nutritional essentiality of sulfur in health and disease


Sulfur is the seventh most abundant element measurable in the human body and is supplied mainly by the intake of methionine (Met), an indispensable amino acid found in plant and animal proteins. Met controls the initiation of protein synthesis, governs major metabolic and catalytic activities, and may undergo reversible redox processes safeguarding protein integrity. Sulfur operates as cofactor of several enzymes critically involved in the regulation of oxidative processes. A combination of malnutrition and nutritional deprivation of sulfur maximizes the risk of cardiovascular disorders and stroke, constituting a novel clinical entity that threatens plant-eating population groups.


Sulfur in Human Nutrition and Applications in Medicine


Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, DMSO, and glucosamine sulfate. Organic sulfur, as SAAs, can be used to increase synthesis of S-adenosylmethionine (SAMe), glutathione (GSH), taurine, and N-acetylcysteine (NAC). MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Other sulfur compounds such as SAMe, dimethylsulfoxide (DMSO), taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS. Dosages, mechanisms of action, and rationales for use are discussed. The low toxicological profiles of these sulfur compounds, combined with promising therapeutic effects, warrant continued human clinical trials.


Antioxidant Effects of Sulfur-Containing Amino Acids


The term thiol refers to compounds containing sulfur. Thiol-containing compounds are found in all body cells and are indispensable for life. Some of these include cysteine, methionine, taurine and glutathione. The number of sulfur atoms determines, at least in part, the modulatory activity on the glutathione-related antioxidant enzymes.


Microbial Sulfur Metabolism


In nature, sulfur occurs in many different oxidation states and is one of the most versatile elements in life. It is an integral part of many important cell constituents, such as the amino acids cysteine and methionine, and many sulfur compounds serve as the basis for energy-related processes in prokaryotes. In recent years, new methods have been applied to study the biochemistry and molecular biology of reactions of the global sulfur cycle, the microorganisms involved and their physiology, metabolism and ecology. These activities have uncovered fascinating new insights for the understanding of aerobic and anaerobic sulfur metabolism.


AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors


This drug has been tested in adults with cancer and in children with some types of brain cancer. This study will test how well this drug works with these types of tumors.


Immediate and delayed effects of treatment at the Dead Sea in patients with psoriatic arthritis


Comparison between groups disclosed a similar statistically significant improvement for variables such as PASI, morning stiffness, patient self-assessment, right and left grip, Schober test and distance from finger to floor when bending forward. For variables such as tender and swollen joints, and inflammatory neck and back pain, an improvement over time was statistically significant in group 1. Addition of mud packs and sulfur baths to sun ultraviolet exposure and Dead Sea baths seems to prolong beneficial effects and improves inflammatory back pain.


Effects of sulfur bath on hip osteoarthritis: a randomized, controlled, single-blind, follow-up trial: a pilot study.


Comparing the results of the two groups at the end of treatment, there was a significant difference in the WOMAC stiffness score only, whereas after 12 weeks, the WOMAC pain, stiffness, function, and total scores also showed a significant difference in favor of the balneotherapy group. The results suggest that the combination of balneotherapy and exercise therapy achieves a more sustained improvement of joint function and decreases in pain than exercise therapy alone.


Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis


Osteoarthritis (OA), the most common form of arthritis, is a public health problem throughout the world. Several entities have been carefully investigated for the symptomatic and structural management of OA. This review evaluates published studies of the effect of glucosamine salts and chondroitin sulfate preparations on the progression of knee or hip OA. There is some evidence to suggest a structure-modifying effect of glucosamine sulfate and chondroitin sulfate. On the basis of the results of recent randomized controlled trials and meta-analyses, we can conclude that glucosamine sulfate (but not glucosamine hydrochloride) and chondroitin sulfate have small-to-moderate symptomatic efficacy in OA, although this is still debated. With respect to the structure-modifying effect, there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with the progression of OA.

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